PEDUNCULATE OAK: Uses, Side Effects, Interactions and Warnings

PEDUNCULATE OAK

Other Names:

Chêne Pédonculé, Corteza de Roble, Eichenrinde, English Oak, European Oak, French Oak, Pelarek, Quercus Cortex, Quercus Pedunculata, Quercus Robur, Tanner's Bark, Tanner's Oak.

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PEDUNCULATE OAK Overview Information

Pedunculate oak (Quercus robur) is a type of oak tree commonly found in Europe. Its bark contains high amounts of antioxidants called ellagitannins.

Pedunculate oak might have anti-inflammatory and antioxidant effects, which are likely due to the ellagitannins in its bark.

People use pedunculate oak for chronic fatigue syndrome (CFS), liver damage caused by alcohol, athletic performance, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.

PEDUNCULATE OAK Uses & Effectiveness

We currently have no information for PEDUNCULATE OAK Uses & Effectiveness

PEDUNCULATE OAK Side Effects & Safety

When taken by mouth: Pedunculate oak wood extract is possibly safe. A specific wood extract (Robuvit, Horphag Research Ltd.) has been used safely for up to 12 weeks.

When applied to the skin: Pedunculate oak leaf extract is possibly safe when used short-term.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if pedunculate oak is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

PEDUNCULATE OAK Interactions

We currently have no information for PEDUNCULATE OAK Interactions

PEDUNCULATE OAK Dosing

A specific pedunculate oak wood extract (Robuvit, Horphag Research Ltd.) has most often been used by adults in doses of 200-600 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View clinical references for this vitamin or supplement Sources

References:

Almeida IF, Fernandes E, Lima JL, Costa PC, Bahia MF. Protective effect of Castanea sativa and Quercus robur leaf extracts against oxygen and nitrogen reactive species. J Photochem Photobiol B. 2008 May 29;91(2-3):87-95. View abstract.

Almeida IF, Valentão P, Andrade PB, et al. Oak leaf extract as topical antioxidant: free radical scavenging and iron chelating activities and in vivo skin irritation potential. Biofactors. 2008;33(4):267-79. View abstract.

Arramon G, Saucier C, Colombani D, Glories Y. Identification of triterpene saponins in Quercus robur L. and Q. petraea Liebl. Heartwood by LC-ESI/MS and NMR. Phytochem Anal. 2002 Nov-Dec;13(6):305-10. View abstract.

Barreneche T, Bodenes C, Lexer C, et al. A genetic linkage map of Quercus robur L.(pedunculate oak) based on RAPD, SCAR, microsatellite, minisatellite, isozyme and 5S rDNA markers. Theoretical and Applied Genetics. 1998 Nov 1;97(7):1090-103.

Belcaro G, Cornelli U, Luzzi R, et al. Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation. Panminerva Med. 2014;56(1):63-72. View abstract.

Belcaro G, Cornelli U, Luzzi R, et al. Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study. J Neurosurg Sci. View abstract.

Belcaro G, Dugall M, Hu S, Ledda A, Ippolito E. French Oak Wood (Quercus robur) Extract (Robuvit) in Primary Lymphedema: A Supplement, Pilot, Registry Evaluation. Int J Angiol. 2015 Mar;24(1):47-54. View abstract.

Belcaro G, Gizzi G, Hu S, et al. Robuvit® (French oak wood extract) in the management of functional, temporary hepatic damage. A registry, pilot study. Minerva Med. 2014 Feb;105(1):41-50. View abstract.

Belcaro G, Gizzi G, Pellegrini L, et al. French oak wood extract (Robuvit®) reduces the wheal and flare response to histamine and decreases capillary filtration in normal subjects. Minerva Biotec. 2013 25(4):199-205.

Deáková Z, Országhová Z, Andrezálová L, et al . Influence of oak wood polyphenols on cysteine, homocysteine and glutathione total levels and PON1 activities in human adult volunteers - a pilot study. Gen Physiol Biophys. 2015 Jan;34(1):73-80. View abstract.

Ferianec V, Fülöp M, Jezovicová M, et al. The Oak-wood Extract Robuvit(®) Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Pilot Study. Nutrients 2020;12(4):913. View abstract.

Glabasnia, A. and Hofmann, T. Sensory-directed identification of taste-active ellagitannins in American (Quercus alba L.) and European oak wood (Quercus robur L.) and quantitative analysis in bourbon whiskey and oak-matured red wines. J Agric.Food Chem 5-3-2006;54(9):3380-3390. View abstract.

Horvathova M, Orszaghova Z, Laubertova L, et al . Effect of the French oak wood extract Robuvit on markers of oxidative stress and activity of antioxidant enzymes in healthy volunteers: a pilot study. Oxid Med Cell Longev. 2014;2014:639868. View abstract.

Lorenz P, Heinrich M, Garcia-Käufer M, et al. Constituents from oak bark (Quercus robur L.) inhibit degranulation and allergic mediator release from basophils and mast cells in vitro. J Ethnopharmacol. 2016 Oct 7. pii: S0378-8741(16)31213-2. View abstract.

Natella F, Leoni G, Maldini M, et al. Absorption, metabolism, and effects at transcriptome level of a standardized French oak wood extract, Robuvit, in healthy volunteers: pilot study. J Agric Food Chem. 2014 Jan 15;62(2):443-53. View abstract.

Országhová Z, Waczulíková I, Burki C, Rohdewald P, Duracková Z. An Effect of Oak-Wood Extract (Robuvit®) on Energy State of Healthy Adults-A Pilot Study. Phytother Res. 2015 Aug;29(8):1219-24. View abstract.

Pellegrini L, Belcaro G, Dugall M, Corsi M, Luzzi R, Hosoi M. Supplementary management of functional, temporary alcoholic hepatic damage with Robuvit® (French oak wood extract). Minerva Gastroenterol Dietol. 2016 62(3):245-252. View abstract.

Piwowarski JP, Granica S, Zwierzynska M, et al. Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. J Ethnopharmacol. 2014 Aug 8;155(1):801-9. View abstract.

Popovic BM, Stajner D, Zdero R, Orlovic S, Galic Z. Antioxidant characterization of oak extracts combining spectrophotometric assays and chemometrics. ScientificWorldJournal. 2013 Dec 25;2013:134656. View abstract.

Salminen JP, Roslin T, Karonen M, Sinkkonen J, Pihlaja K, Pulkkinen P. Seasonal variation in the content of hydrolyzable tannins, flavonoid glycosides, and proanthocyanidins in oak leaves. J Chem Ecol. 2004 Sep;30(9):1693-711. View abstract.

Trebatická J, Duracková Z. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? Oxid Med Cell Longev. 2015;2015:248529. View abstract.

Vinciguerra MG, Belcaro G, Cacchio M. Robuvit® and endurance in triathlon: improvements in training performance, recovery and oxidative stress. Minerva Cardioangiol. 2015 Oct;63(5):403-9. View abstract.

Weber RW. Allergen of the Month--English Oak. Ann Allergy Asthma Immunol. 2015 Nov;115(5):A13. View abstract.

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