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NICOTINAMIDE RIBOSIDE

Other Names:

Nicotinamide Ribose, NR, Riboside de nicotinamide.

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NICOTINAMIDE RIBOSIDE Overview Information

Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk.

Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.

People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.

Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.

NICOTINAMIDE RIBOSIDE Uses & Effectiveness

We currently have no information for NICOTINAMIDE RIBOSIDE Uses & Effectiveness

NICOTINAMIDE RIBOSIDE Side Effects & Safety

When taken by mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.

NICOTINAMIDE RIBOSIDE Interactions

Moderate Interaction Be cautious with this combination

Medications for high blood pressure (Antihypertensive drugs) interacts with NICOTINAMIDE RIBOSIDE
Nicotinamide riboside might lower blood pressure. Taking nicotinamide riboside along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

NICOTINAMIDE RIBOSIDE Dosing

There isn't enough reliable information to know what an appropriate dose of nicotinamide riboside might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View clinical references for this vitamin or supplement Sources

References:

Airhart SE, Shireman LM, Risler LJ, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One 2017;12(12):e0186459. View abstract.

Braidy N, Berg J, Clement J, et al. Role of nicotinamide dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry, pharmacokinetics, and outcomes. Antiox Redox Signal 2018. View abstract.

Brakedal B, Dölle C, Riemer F, et al. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab 2022;34(3):396-407. View abstract.

Brown KD, Maqsood S, Huang JY, et al. Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss. Cell Metab 2014;20(6):1059-68. View abstract.

Cartwright DM, Oakey LA, Fletcher RS, et al. Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity. J Endocrinol 2021;251(1):111-123. View abstract.

Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care 2013;16(6):657-61. View abstract.

Close GL, Hamilton DL, Philp A, Burke LM, Morton JP. New strategies in sport nutrition to increase exercise performance. Free Radic Biol Med 2016;98:144-58. View abstract.

Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. View abstract.

de Castro JM, Stein DJ, Medeiros HR, de Oliveira C, Torres ILS. Nicotinamide Riboside Neutralizes Hypothalamic Inflammation and Increases Weight Loss Without Altering Muscle Mass in Obese Rats Under Calorie Restriction: A Preliminary Investigation. Front Nutr 2021;8:648893. View abstract.

Dellinger RW, Holmes HE, Hu-Seliger T, et al. Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial. Hepatology 2022. View abstract.

Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17. View abstract.

Diguet N, Trammell SAJ, Tannous C, et al. Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy. Circulation 2018;137(21):2256-73. Erratum in: Circulation 2018;137(21):e690. View abstract.

Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. View abstract.

Dollerup OL, Chubanava S, Agerholm M, et al. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 2019 [Epub ahead of print]. View abstract.

Dollerup OL, Trammell SAJ, Hartmann B, et al. Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in nondiabetic men with obesity. J Clin Endocrinol Metab 2019;104(11):5703-14. View abstract.

Dolopikou CF, Kourtzidis IA, Margaritelis NV, et al. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. Eur J Nutr 2019 [Epub ahead of print]. View abstract.

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843. View abstract.

Elhassan YS, Philp AA, Lavery GG. Targeting NAD+ in metabolic disease: new insights into an old molecule. J Endocr Soc 2017;1(7):816-35. View abstract.

Gong B, Pan Y, Vemati P, et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-? coactivator 1a regulated ß-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Nuerobiol Aging 2013;34(6):1581-8. View abstract.

Han X, Bao X, Lou Q, et al. Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice. PeerJ 2019;7:e7568. View abstract.

Hong G, Zheng D, Zhang L, et al. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free Radic Biol Med 2018;123:125-37. View abstract.

Jensen JB, Dollerup OL, Møller AB, et al. A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight 2022;7(19):e158314. View abstract.

Johnson S, Imai SI. NAD+ biosynthesis, aging, and disease. F1000Res 2018;7:132. View abstract.

Kim MB, Pham TX, vanLuling M, et al. Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice. J Nutr Biochem 2022;107:109058. View abstract.

Lee HJ, Yang SJ. Supplementation with nicotinamide riboside reduces brain inflammation and improves cognitive function in diabetic mice. Int J Mol Sci 2019;20(17). pii: E4196. View abstract.

Maric T, Bazhin A, Khodakivskyi P, et al. A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism [published online ahead of print, 2022 Oct 29]. Biosens Bioelectron. 2022;220:114826. View abstract.

Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. View abstract.

Perna S, Giacosa A, Bonitta G, et al. Effects of hazelnut consumption on blood lipids and body weight: a systematic review and Bayesian meta-analysis. Nutrients 2016;8(12). pii: E747. View abstract.

Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. View abstract.

Seldeen KL, Shahini A, Thiyagarajan R, et al. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors. Nutrition 2021;87-88:111189. View abstract.

Shi W, Hegeman MA, Doncheva A, Bekkenkamp-Grovenstein M, de Boer VCJ, Keijer J. High dose of dietary nicotinamide riboside induces glucose intolerance and white adipose tissue dysfunction in mice fed a mildly obesogenic diet. Nutrients 2019;11(10). pii: E2439. View abstract.

Stocks B, Ashcroft SP, Joanisse S, et al. Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise. J Physiol. 2021. View abstract.

Teijeiro A, Djouder N. Nicotinamide riboside or IL-17A signaling blockers to prevent liver disorders. Oncoscience 2017;4(1-2):1-2. View abstract.

Trammell SA, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun 2016;7:12948. View abstract.

Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C. Nicotinamide riboside is a major NAD+ precursor vitamin in cow milk. J Nutr 2016;146(5):957-63. View abstract.

Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e05775. View abstract.

Veenhuis SJG, van Os NJH, Janssen AJWM, et al. Nicotinamide Riboside Improves Ataxia Scores and Immunoglobulin Levels in Ataxia Telangiectasia. Mov Disord 2021;36(12):2951-2957. View abstract.

Wang DD, Airhart SE, Zhou B, et al. Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction. JACC Basic Transl Sci 2022;7(12):1183-1196. View abstract.

Xie X, Gao Y, Zeng M, et al. Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer's disease model mice. Metab Brain Dis 2019;34(1):353-66. View abstract.

Yoshino J, Baur JA, Imai SI. NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab 2018;27(3):513-28. View abstract.

Zhang X, Henneman NF, Girardot PE, Sellers JT, Chrenek MA, Li Y, Wang J, Brenner C, Nickerson JM, Boatright JH. Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration. Invest Ophthalmol Vis Sci. 2020;61(10):47. View abstract.

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