AGMATINE Overview Information
Agmatine is a chemical found in bacteria, plants, and animals, including humans. It is made from the amino acid known as arginine.
Agmatine is commonly used by mouth for depression, nerve pain, improving athletic performance, and many more conditions. But there is limited scientific research to support any of these uses.
How does it work?
Agmatine seems to help manage different chemicals and pathways in the brain. This might improve certain conditions of the brain and nervous system.
AGMATINE Uses & Effectiveness 
Insufficient Evidence for:
- Herniated disc. Early research shows that taking agmatine might decrease pain and increase quality of life in people with nerve pain due to a herniated disc.
- Alcohol use disorder.
- Alzheimer disease.
- Anxiety.
- Athletic performance.
- Autism.
- Bipolar disorder.
- Depression.
- Nerve pain.
- Parkinson disease.
- Seizures.
- Schizophrenia.
- Stroke.
- Other conditions.
AGMATINE Side Effects & Safety
There isn't enough reliable information to know if agmatine is safe. Some people taking agmatine have had side effects such as diarrhea, upset stomach, and nausea.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking agmatine if you are pregnant or breast feeding. Stay on the safe side and avoid use.Diabetes: Agmatine might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use agmatine.
Surgery: Agmatine might lower blood sugar and blood pressure and could interfere with blood sugar and blood pressure control during and after surgery. Stop taking agmatine at least 2 weeks before a scheduled surgery.
AGMATINE Interactions
Moderate Interaction Be cautious with this combination
- Medications for diabetes (Antidiabetes drugs) interacts with AGMATINE
Agmatine might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking agmatine along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. - Medications for high blood pressure (Antihypertensive drugs) interacts with AGMATINE
Using agmatine with drugs that lower blood pressure may increase the effects of these drugs and may lower blood pressure too much.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
AGMATINE Dosing
The appropriate dose of agmatine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for agmatine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
