N,N-DMPEA Overview Information
N,N-dimethylphenethylamine (N,N-DMPEA) is a chemical. It is a form of phenethylamine.
Some people apply N,N-DMPEA to the eyes for dry eye or take N,N-DMPEA by mouth for weight loss and athletic performance. But there is no good scientific evidence to support these uses.
N,N-DMPEA is also used in small amounts for flavoring in foods.
How does it work?
N,N-DMPEA might affect certain chemicals in the brain. But there isn't enough reliable information available to know how N,N-DMPEA might work in humans.
N,N-DMPEA Uses & Effectiveness 
Insufficient Evidence for:
N,N-DMPEA Side Effects & Safety
When taken by mouth: N,N-DMPEA is LIKELY SAFE when used in small amounts for food flavor. N,N-DMPEA is POSSIBLY UNSAFE when taken by mouth in medicinal amounts. Stroke has been reported by a woman who took a supplement that listed N,N-DMPEA and other ingredients on the label.
When applied into the eye: N,N-DMPEA is POSSIBLY SAFE when applied into the eye as eye drops for up to 21 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if N,N-DMPEA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.N,N-DMPEA Interactions
Moderate Interaction Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with N,N-DMPEA
Some medications are changed and broken down by the liver. N,N-DMPEA might decrease how quickly the liver breaks down some medications. Taking N,N-DMPEA along with some medications that are changed by the liver might increase the effects and side effects of your medication. Before taking N,N-DMPEA, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
N,N-DMPEA Dosing
The appropriate dose of N,N-DMPEA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for N,N-DMPEA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
