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GLUCURONOLACTONE

Other Names:

D-Glucurono-1,4-lactone, D-Glucurono-3,6-lactone, D-Glucurono-gamma-lactone, D-Glucuronolactone.

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GLUCURONOLACTONE Overview Information

Glucuronolactone is a chemical. It can be made by the body. It is also found in foods and made in laboratories.

Glucuronolactone is commonly used as an ingredient in "energy" drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use.

How does it work?

There isn't enough information to know how glucuronolactone might work as a medicine.

GLUCURONOLACTONE Uses & Effectiveness

Insufficient Evidence for:

Liver damage caused by tuberculosis drugs.
Preventing liver damage.
Increasing attention.
Athletic performance.
Other conditions.

More evidence is needed to rate the effectiveness of glucuronolactone for these uses.

GLUCURONOLACTONE Side Effects & Safety

When taken by mouth: Glucuronolactone is LIKELY SAFE when used in food amounts. There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth in higher amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if glucuronolactone is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children:There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth. Stay on the safe side and stick to food amounts.

GLUCURONOLACTONE Interactions

We currently have no information for GLUCURONOLACTONE Interactions

GLUCURONOLACTONE Dosing

The appropriate dose of glucuronolactone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glucuronolactone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View clinical references for this vitamin or supplement Sources

References:

Basrai M, Schweinlin A, Menzel J, et al. Energy drinks induce acute cardiovascular and metabolic changes pointing to potential risks for young adults: A randomized controlled trial. J Nutr. 2019;149(3):441-450. View abstract.

Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clin Proc. 2010;85(11):1033-41. View abstract.

Marsh CA. Metabolism of d-glucuronolactone in mammalian systems. 2. Conversion of d-glucuronolactone into d-glucaric acid by tissue preparations. Biochem J. 1963;87(1):82-90. View abstract.

Marsh CA. Metabolism of d-glucuronolactone in mammalian systems. Identification of d-glucaric acid as a normal constituent of urine. Biochem J. 1963;86(1):77-86. View abstract.

Marsh CA. Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action. Biochem J. 1966;99(1):22-7. View abstract.

Opinion of the panel on food additives, flavourings, processing aids, materials in contact with food and cosmetics of the Norwegian Scientific Committee for Food Safety: Risk assessment of "other substances" -D-glucurono-?-lactone. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=2ahUKEwiDpsKY2JXoAhWCqp4KHfEiDjkQFjAEegQIBBAB&url=https%3A%2F%2Fvkm.no%2Fdownload%2F18.645b840415d03a2fe8f260ad%2F1502803227005%2FRisk%2520assessment%2520of%2520%2522other%2520substances%2522%2520%25E2%2580%2593%2520D-Glucurono-%25CE%25B3-lactone.pdf&usg=AOvVaw0KHxHAYpQMwH-qbTiiuzV8. Accessed June 24, 2020.

Tamura S, Tsutsumi S, Ito H, Nakai K, Masuda M. Effects of glucuronolactone and the other carbohydrates on the biochemical changes produced in the living body of rats by hard exercise. Jpn J Pharmacol. 1968;18(1):30-8. View abstract.

The use of taurine and D-glucurono-?-lactone as constituents of the so-called "energy" drinks. European Food Safety Authority. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2009.935. Accessed June 24, 2020.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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