ADRAFINIL Overview Information
Adrafinil is a stimulant related to the drug modafinil (Provigil). It's found in some supplements called nootropics, which are marketed for memory or attention.
Adrafinil has effects similar to modafinil, which is a prescription drug that is used to treat narcolepsy.
People use adrafinil for aging, athletic performance, mental alertness, obesity, opioid withdrawal, and many other conditions, but there is no good scientific evidence to support these uses. It might also be unsafe.
Adrafinil is banned by the World Anti-Doping Agency (WADA).
ADRAFINIL Uses & Effectiveness 
We currently have no information for ADRAFINIL Uses & Effectiveness
ADRAFINIL Side Effects & Safety
When taken by mouth: Adrafinil is possibly unsafe. It might lead to serious heart or psychiatric-related side effects. It may also be addictive.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Adrafinil is possibly unsafe when taken by mouth while pregnant or breast-feeding. It might cause a miscarriage or lead to developmental problems for the infant. Avoid use.Heart conditions: Adrafinil is a stimulant that might cause irregular heartbeat or increase blood pressure. This might worsen existing heart conditions. People with heart conditions should avoid use.
Elderly people: Elderly people might be more likely to experience serious side effects from adrafinil.
High blood pressure: People with high blood pressure should avoid adrafinil. It might increase blood pressure even more.
Liver disease: Adrafinil is processed in the liver. People with liver disease might be unable to process it properly. This might increase the risk for side effects.
A mental disorder marked by hallucinations and delusion (psychosis): Adrafinil might make existing psychosis worse. Avoid use.
ADRAFINIL Interactions
Major Interaction Do not take this combination
- Modafinil (Provigil) interacts with ADRAFINIL
Adrafinil has effects similar to the drug modafinil. Taking adrafinil with modafinil might increase the effects and side effects of modafinil.
Moderate Interaction Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ADRAFINIL
Some medications are changed and broken down by the liver. Adrafinil might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates) interacts with ADRAFINIL
Some medications are changed and broken down by the liver. Adrafinil might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with ADRAFINIL
Some medications are changed and broken down by the liver. Adrafinil might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with ADRAFINIL
Some medications are changed and broken down by the liver. Adrafinil might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with ADRAFINIL
Some medications are changed and broken down by the liver. Adrafinil might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications for depression (MAOIs) interacts with ADRAFINIL
Adrafinil has effects similar to the drug modafinil. Taking modafinil with MAOIs has led to serious side effects.
Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate). - Medications for high blood pressure (Antihypertensive drugs) interacts with ADRAFINIL
Adrafinil might increase blood pressure. Taking adrafinil might reduce the effects of blood pressure medications. Monitor your blood pressure closely.
- Medications that decrease break down of other medications in the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors) interacts with ADRAFINIL
Adrafinil is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down adrafinil. This could change the effects and side effects of adrafinil.
- Stimulant drugs interacts with ADRAFINIL
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Adrafinil might also speed up the nervous system. Taking adrafinil along with stimulant drugs might increase the risk for serious heart or psychiatric effects.
- Warfarin (Coumadin) interacts with ADRAFINIL
Adrafinil has effects similar to the drug modafinil. Taking modafinil with warfarin might change the effects and side effects of warfarin. You warfarin dose might need to be changed.
ADRAFINIL Dosing
There isn't enough reliable information to know what an appropriate dose of adrafinil might be. It might also be unsafe. Speak with your healthcare provider before use.
