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DELTA - 8 - TETRAHYDROCANNABINOL (DELTA - 8 - THC)

Other Names:

Delta-8-Tetrahydrocannabinol, Delta-8-THC, Diet Weed, Weed Light.

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DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Overview

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Uses

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Side Effects

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Interactions

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Dosing

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Overview Information

Delta-8-tetrahydrocannabinol (delta-8-THC) is a cannabinoid from Cannabis sativa. It's similar to delta-9-THC, the main psychoactive compound in cannabis.

Cannabinoids in cannabis work by binding to sites in the brain and on the nerves. Delta-8-THC is similar to delta-9-THC, but appears to be less psychoactive. The natural concentration of delta-8-THC in cannabis and hemp is low, so most delta-8-THC is synthetically made in a lab.

People use delta-8-THC for nausea and vomiting caused by cancer drug treatment, glaucoma, trouble sleeping, and many other conditions, but there is no good scientific evidence to support these uses.

Keep in mind that delta-8-THC hasn't been evaluated by the US FDA for safety, and legality isn't clear. It's banned in some states, and legal in others. Also, the amount of delta-8-THC in products might vary significantly. Some products might also contain contaminants.

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Uses & Effectiveness

We currently have no information for DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Uses & Effectiveness

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Side Effects & Safety

When taken by mouth: There isn't enough reliable information to know if delta-8-THC is safe. It might cause side effects such as difficulty thinking and speaking, and feeling "high." Regular use might also cause cannabinoid hyperemesis syndrome (CHS). CHS leads to severe nausea and vomiting that doesn't respond to typical anti-nausea drugs.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if delta-8-THC is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: Taking delta-8-THC by mouth is possibly unsafe. Delta-8-THC gummies and candies have been eaten by children by mistake, leading to hospitalization. Side effects might include extreme tiredness, low blood pressure, and slowed heart rate.

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Interactions

We currently have no information for DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Interactions

DELTA-8-TETRAHYDROCANNABINOL DELTA-8-THC Dosing

Delta-8-THC is available in many different types of products, including foods, dried plant products, and smoking and vaping products. The amount of delta-8-THC in products might vary significantly. Some products might also contain contaminants. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Keep in mind that delta-8-THC hasn't been evaluated by the US FDA for safety, and legality isn't clear. It's banned in some states, and legal in others.

View clinical references for this vitamin or supplement Sources

References:

Akpunonu P, Baum RA, Reckers A, et al. Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies. Am J Case Rep 2021;22:e933488. View abstract.

Avraham Y, Ben-Shushan D, Breuer A, et al. Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss. Pharmacol Biochem Behav 2004;77(4):675-84. View abstract.

Centers for Disease Control and Prevention (CDC). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. September 2021. https://emergency.cdc.gov/han/2021/han00451.asp. Accessed October 2, 2021.

Crippa JAS, Zuardi AW, Hallak JEC, et al. Oral cannabidiol does not convert to ?(8)-THC or ?(9)-THC in humans: A pharmacokinetic study in healthy subjects. Cannabis Cannabinoid Res 2020;5(1):89-98. View abstract.

Czégény Z, Nagy G, Babinszki B, et al. CBD, a precursor of THC in e-cigarettes. Sci Rep 2021;11(1):8951. View abstract.

Jo NY, Chu CC, Ramsey BC. Brugada Electrocardiogram Pattern Induced by Recreational Delta-8-Tetrahydrocannabinol (THC): A Case Report. Cureus 2021;13(10):e19058. View abstract.

Johnson-Arbor K, Smolinske S. The current state of delta-8 THC. Am J Emerg Med 2021. View abstract.

Loveless SE, Harris LS, Munson AE. Hyporesponsiveness to the immunosuppressant effects of delta-8-tetrahydrocannabinol. J Immunopharmacol 1981;3(3-4):371-83. View abstract.

Meehan-Atrash J, Rahman I. Novel ?(8)-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals. Chem Res Toxicol 2021. View abstract.

Rosenthal J, Howell M, Earl V, Malik M. Cannabinoid hyperemesis syndrome secondary to delta-8 THC use. Am J Med 2021. View abstract.

Rzeppa S, Große J, Rautenberg C, et al. Emergence of the less common cannabinoid ?8 -Tetrahydrocannabinol in a doping sample. Drug Test Anal. 2021. View abstract.

Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014;46(1):86-95. View abstract.

US Food and Drug Administration (FDA). 5 things to know about delta-8 tetrahydrocannabinol - delta-8 THC. September 2021. https://www.fda.gov/consumers/consumer-updates/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc. Accessed October 2, 2021.

Watanabe K, Arai M, Narimatsu S, Yamamoto I, Yoshimura H. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice. Biochem Pharmacol 1986;35(11):1861-5. View abstract.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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