TERMINALIA CHEBULA

Other Names:

Abhaya, Badamier chebule, Bala Harade, Black yrobalan, Chebulic Myrobalan, Chebulische, Gall nut, Gallnut, Halela Zard, Hara, Harad, Harade, Harada, Harra, Harro, He li le, He Zi, Indian gall nut, Indian gallnut, Indian gall-nut, Ink nut, Jangal...
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TERMINALIA CHEBULA Overview Information

Terminalia chebula is a tree that grows throughout India, Burma, Sri Lanka, and Mauritius. Its fruit is called Haritaki and is used in Ayurvedic medicine.

The fruit of the Terminalia chebula tree contains chemicals that might have pain-relieving affects. It might also reduce blood sugar.

People use Terminalia chebula for aging skin, constipation, diabetes, diarrhea, high cholesterol, osteoarthritis, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse Terminalia chebula with other Terminalia species, including Terminalia bellirica and Terminalia arjuna. These are not the same.

TERMINALIA CHEBULA Uses & Effectiveness

We currently have no information for TERMINALIA CHEBULA Uses & Effectiveness

TERMINALIA CHEBULA Side Effects & Safety

When taken by mouth: Terminalia chebula is possibly safe when used for up to 8 weeks. There isn't enough reliable information to know what the side effects from Terminalia chebula might be.

When applied to the skin: Terminalia chebula is possibly safe when used for up to 40 days. There isn't enough reliable information to know what the side effects from Terminalia chebula might be.

Special Precautions & Warnings:

Pregnancy: Terminalia chebula is possibly unsafe when taken by mouth during pregnancy. Stay on the safe side and avoid use.

Breast-feeding: There isn't enough reliable information to know if Terminalia chebula is safe to use when breast-feeding. Stay on the safe side and avoid use.

Surgery: Terminalia chebula might interfere with blood sugar control during surgery. Stop taking Terminalia chebula at least 2 weeks before a scheduled surgery.

TERMINALIA CHEBULA Interactions

Moderate Interaction Be cautious with this combination

Chlorzoxazone (Parafon Forte, Paraflex) interacts with TERMINALIA CHEBULA
The body breaks down chlorzoxazone to get rid of it. Terminalia chebula might decrease how quickly the body breaks down chlorzoxazone. Taking Terminalia along with chlorzoxazone might increase the effects and side effects of chlorzoxazone.
Medications for diabetes (Antidiabetes drugs) interacts with TERMINALIA CHEBULA
Terminalia chebula might lower blood sugar levels. Taking Terminalia chebula along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Omeprazole (Prilosec) interacts with TERMINALIA CHEBULA
The body breaks down omeprazole to get rid of it. Terminalia chebula might decrease how quickly the body breaks down omeprazole. Taking Terminalia chebula along with omeprazole might increase the effects and side effects of omeprazole.

TERMINALIA CHEBULA Dosing

Terminalia chebula has most often been used by adults in doses of 400-600 mg by mouth daily for up to 3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View clinical references for this vitamin or supplement Sources

References:

Murali, Y. K., Anand, P., Tandon, V., Singh, R., Chandra, R., and Murthy, P. S. Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced diabetic rats. Exp.Clin Endocrinol.Diabetes 2007;115(10):641-646. View abstract.

Patel, R. K., Gondaliya, D. P., and Subramanian, S. Evaluation of commercial "Haradae" (Terminalia chebula). Indian Journal of Natural Products (India) 2004;19:511-518.

Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. View abstract.

Senthilkumar, G. P. and Subramanian, S. Evaluation of antioxidant potential of Terminalia chebula fruits studies in streptozotocin-induced diabetic rats. Pharmaceutical Biology (Netherlands) 2007;45:511-518.

Agrawal OD, Kulkarni YA. Treatment with Terminalia chebula extract reduces insulin resistance, hyperglycemia and improves SIRT1 expression in type 2 diabetic rats. Life (Basel) 2023;13(5):1168. View abstract.

Aneja KR, Sharma C, Joshi R. Antimicrobial activity of Terminalia arjuna Wight & Arn.: an ethnomedicinal plant against pathogens causing ear infection. Braz J Otorhinolaryngol. 2012;78(1):68-74. View abstract.

Banazadeh M, Mehrabani M, Banazadeh N, Dabaghzadeh F, Shahabi F. Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double-blind, placebo-controlled trial. Phytother Res 2022;36(1):543-550. View abstract.

Chakkalakal M, Pan A, Nadora D, et al. Randomized double-blind placebo-controlled supplementation with standardized Terminalia chebula fruit extracts reduces facial sebum excretion, erythema, and wrinkle severity. J Clin Med 2023;12(4):1591. View abstract.

Chevallier A. Encyclopedia of Medicinal Plants. New York, NY: DK Publishing, 1996.

Das A, Naveen J, Sreerama YN, Gnanesh Kumar BS, Baskaran V. Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit a-amylase, a-glucosidase and DPP-IV activity in high fat and low dose streptozotocin-induced diabetic rat. J Food Sci Technol 2022;59(6):2177-2188. View abstract.

Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-225. View abstract.

el-Mekkawy S, Meselhy MR, Kusumoto IT, et al. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull (Tokyo) 1995;43:641-8. View abstract.

Eltimamy M, Elshamarka M, Aboelsaad M, Sayed M, Moawad H. Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats. J Diabetes Metab Disord 2022;21(1):159-170. View abstract.

Haghani M, Jafari M, Meftahi GH, et al. Analgesic effects of Terminalia chebula extract are mediated by the suppression of the protein expression of nerve growth factor and nuclear factor-?B in the brain and oxidative markers following neuropathic pain in rats. Mol Biol Rep 2022;49(11):10457-10467. View abstract.

Hamada S, Kataoka T, Woo JT, et al. Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity. Biol Pharm Bull 1997;20:1017-9. View abstract.

Jagtap AG, Karkera SG. Potential of the aqueous extract of Terminalia chebula as an anticaries agent. J Ethnopharmacol 1999;68:299-306. View abstract.

Karlapudi V, Prasad Mungara AVV, Sengupta K, Davis BA, Rachaudhuri SP. A placebo-controlled double-blind study demonstrates the clinical efficacy of a novel herbal formulation for relieving joint discomfort in human subjects with osteoarthritis of knee. J Med Food. 2018 May;21(5):511-520. View abstract.

Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res 1995;27:19-37. View abstract.

Kwandee P, Somnuk S, Wanikorn B, Nakphaichit M, Tunsagool P. Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model. J Tradit Complement Med 2023;13(2):207-217. View abstract.

Mani V, Sajid S, Rabbani SI, Alqasir AS, Alharbi HA, Alshumaym A. Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice. J Tradit Complement Med 2021;11(6):493-502. View abstract.

Phadke SA, Kulkarni SD. Screening of in vitro antibacterial activity of Terminalia chebula, Eclapta alba and Ocimum sanctum. Indian J Med Sci 1989;43:113-7. View abstract.

Pingali U, Sukumaran D, Nutalapati C. Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical study. Phytother Res 2020;34(12):3226-3235. View abstract.

Sato Y, Oketani H, Singyouchi K, et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula RETS. against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull 1997;20:401-4. View abstract.

Shaila HP, Udupa SL, Udupa AL. Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis. Int J Cardiol 1998;67:119-214. View abstract.

Shokoohi R, Kianbakht S, Faramarzi M, Rahmanian M, Nabati F, Mehrzadi S, Huseini HF. Effects of an herbal combination on glycemic control and lipid profile in diabetic women: a randomized, double-blind, placebo-controlled clinical trial. J evid Baed Complementary Altern Med. 2017 Oct;22(4):798-804. View abstract.

Suthienkul O, Miyazaki O, Chulasiri M, et al. Retroviral reverse transcriptase inhibitory activity in Thai herbs and spices: screening with Moloney murine leukemia viral enzyme. Southeast Asian J Trop Med Public Health 1993;24:751-5. View abstract.

Tasneem Parapur S, Husain N, Khalid M, Mamdapur SAR, Kauser Khan KA. Evaluation of the efficacy of topical Terminalia chebula Retz. with vinegar in the treatment of tinea corporis: a non-inferiority randomized controlled trial. Drug Metab Pers Ther 2023. View abstract.

Thakur CP, Thakur B, Singh S, et al. The Ayurvedic medicines Haritaki, Amala and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int J Cardiol 1988;21:167-75. View abstract.

Wu G, Dong Z, Dong J, et al. Effects of mongolian medicine Terminalia chebula Retz. on 6 CYP450 enzymes in rats. Int J Clin Exp Pathol 2020;13(12):3128-3138. View abstract.

Yao G, Miao X, Wu M, et al. Pharmacokinetics of active compounds of a Terminalia chebula Retz. Ethanolic extract after oral administration rats using UPLC-MS/MS. Front Pharmacol 2023;14:1067089. View abstract.

Yukawa TA, Kurokawa M, Sato H, et al. Prophylactic treatment of cytomegalovirus infection with traditional herbs. Antiviral Res 1996;32:63-70. View abstract.

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