Reviewer: Amy, 55-64 Female on Treatment for less than 1 month (Consumer)

Comment:
I wanted to try this mainly for depression. I have anxiety as well that I've been managing pretty well. This helped so much with hip pain and depression but I'm now feeling so much anxiety, even waking up at night with panic attacks. I'm going to have to stop taking it and see if I sleep better.

Comment:
I wanted to try this mainly for depression. I have anxiety as well that I've been managing pretty well. This helped so much with hip pain and depression but I'm now feeling so much anxiety, even waking up at night with panic attacks. I'm going to have to stop taking it and see if I sleep better.
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Reviewer: SamBraven, 45-54 Male on Treatment for less than 1 month (Consumer)

Comment:
I have moderate depression, mostly seasonal (Seasonal Affective Disorder) but also bouts outside of Winter. I also have moderate GAD (Generalized Anxiety Disorder). I'm a research'o'holic and tried many supplements for various conditions. I started enteric coated SAMe 400mg total at 200mg twice a day (once in morning, once at lunch) for a week. Didn't notice much. I started l ... Show Full Comment

Comment:
I have moderate depression, mostly seasonal (Seasonal Affective Disorder) but also bouts outside of Winter. I also have moderate GAD (Generalized Anxiety Disorder). I'm a research'o'holic and tried many supplements for various conditions. I started enteric coated SAMe 400mg total at 200mg twice a day (once in morning, once at lunch) for a week. Didn't notice much. I started low to ensure no stomach issues. I read research that the 800mg-1,600mg was most common in studies so upped dose to 400mg twice a day = 800mg. That made the difference. More energe, elevated mood, more motivation, but after about a week on 800mg a day, started to notice I was feeling TOO "up" and started to have moderate anxious feeling, borderline full blown anxiety, all day. Also had consistent negative (aka "bad") dreams. So thanks but no thanks SAMe. Going to switch to Acetyl L-Carnitine (the concerns about TMAO and heart disease have since been debunked in other studies) and see how that goes.
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Reviewer: Angel, 19-24 Female on Treatment for 1 to 6 months (Consumer)

Brand Product: Other

Comment:
At first, everything was wonderful. I felt relief from my depression once the sam-e had time to kick in/process and it was like a weight off my shoulders. My depression didn't vanish completely, but it was far easier to manage and i felt a marked increase in emotional stability that i hadn't felt for a long time. However, after a few months of taking sam-e I began to notice side effect ... Show Full Comment

Comment:
At first, everything was wonderful. I felt relief from my depression once the sam-e had time to kick in/process and it was like a weight off my shoulders. My depression didn't vanish completely, but it was far easier to manage and i felt a marked increase in emotional stability that i hadn't felt for a long time. However, after a few months of taking sam-e I began to notice side effects. My anxiety became so severe that I could scarcely breathe and was left constantly short of breath and struggling to draw breath, and I was having heart palpitations regularly. I also occasionally suffered from stomach pains. All of this went away after I stopped taking the sam-e, I haven't taken it since or had the same issues since I stopped taking it. I was taking 400 mg per day of Nature's Trove sam-e in the mornings before eating.
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Reviewer: 45-54 Male (Consumer)

Comment:
Have taken this several times and the effects always the same. Feel ok for an hour or so followed by awful anxiety for the rest of the day..

Comment:
Have taken this several times and the effects always the same. Feel ok for an hour or so followed by awful anxiety for the rest of the day..
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Reviewer: zebra.dkj, 55-64 on Treatment for 1 to less than 2 years (Consumer)

Comment:
Diagnosed w PTSD following a lengthy and complicated medical issue resulting in multiple surgeries, invasive testing, consultations and malpractice and severe pain. Hesitant to try any meds for what I assumed was a temporary situation. After reading "Healing Anxiety and Depression" by Amen

Comment:
Diagnosed w PTSD following a lengthy and complicated medical issue resulting in multiple surgeries, invasive testing, consultations and malpractice and severe pain. Hesitant to try any meds for what I assumed was a temporary situation. After reading "Healing Anxiety and Depression" by Amen
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